The Vampiro is a traditional Mexican cocktail. Its main ingredients are tequila, citrus juice (typically lime), orange juice, a citrus-flavored soda (most commonly Squirt or Fresca), and sometimes tomato juice or sangrita. It is usually seasoned with salt and chili powder. The drink is typically served over ice in a highball glass or a clay mug called a “jarrito.” The rim is often coated with salt and chili powder.

The cocktail is known for its balance of savory, sweet, sour, and spicy flavors. The addition of tomato juice or sangrita gives the drink its distinctive red color, which, combined with its name ("vampire" in Spanish), references blood. The use of Squirt soda, a grapefruit-flavored drink, is traditional in many parts of Mexico but may be substituted with other citrus sodas.

The origins of the Vampiro are not precisely documented, but the drink is believed to have emerged in the 1990s in the state of Jalisco, the heartland of tequila production. A popular story attributes its invention to fruit and snack vendors in San Luis Soyatlán, Jalisco, who started mixing tequila with Squirt, salt, chili powder, and citrus juices for local customers. The cocktail became popular with truck drivers who stopped at roadside stands. Its popularity spread throughout Mexico and eventually to bars and restaurants internationally.

The Vampiro is sometimes compared to the Bloody Mary due to the presence of tomato juice and its savory notes, but it has a different flavor profile because of tequila and citrus soda. The International Bartenders Association (IBA) does not officially recognize the Vampiro as a classic cocktail, but it is a staple in Mexican celebrations and social gatherings.